Neurocognitive impairment in HIV+ people living with good immune figures: the early Diagnosis

Keywords

AIDS dementia complex
Dementia
HIV
Neurocognitive impairment
Diagnosis

How to Cite

1.
Lage Costa SA, Bendezu K. Neurocognitive impairment in HIV+ people living with good immune figures: the early Diagnosis. International Journal of Neurology [Internet]. 2024 Dec. 30 [cited 2026 Jan. 26];58:52. Available from: https://ijneurology.org/index.php/ijn/article/view/52

Abstract

Introduction: Neurocognitive impairments in patients living with human immunodeficiency virus are a cause for concern in clinical practice due to the increasing prevalence of these disorders, even in patients undergoing antiretroviral therapy and with good immune status. With the central nervous system as one of its reservoirs, the human immunodeficiency virus is a risk factor for cognitive disorders, and early diagnosis of dementia or other mental conditions is important for patient management. Materials and methods: An advanced search was conducted in PubMed to select relevant scientific articles, in addition to researching data on the websites of the U.S. Department of Health and Human Services and the World Health Organization. The information takes into account HIV+ patients who have presented mild, moderate, or severe cognitive impairment in the last 30 years. Results: Dozens of articles in English were found that consolidate this systematic review on the importance of early diagnosis in this population. Conclusion: Early identification of neurocognitive impairment is essential for its ideal therapeutic management in order to slow its progression and improve patients' quality of life.

References

1. Full text. J Clin Epidemiol [Internet]. Disponible en: https://www.jclinepi.com/article/S0895-4356(01)00445-0/fulltext

2. An HIV testing conundrum: balancing the health and ethical considerations. Continuum (Minneap Minn) [Internet]. Disponible en: https://journals.lww.com/continuum/Abstract/2012/12000/An_HIV_Testing_Conundrum_Balancing_the_Health_and.10.aspx

3. HIV-associated neurocognitive disorders. Curr Opin HIV AIDS [Internet]. Disponible en: https://link.springer.com/article/10.1007/s11904-016-0319-7

4. HIV persistence in the central nervous system. AIDS [Internet]. Disponible en: https://journals.lww.com/aidsonline/fulltext/2019/12012/hiv_persistence_in_the_central_nervous_system.1.aspx

5. Neurocognitive impairment in HIV infection. J Neurovirol [Internet]. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0169409X1630059X

6. Cognitive disorders in HIV. Prog Neuropsychopharmacol Biol Psychiatry [Internet]. Disponible en: https://www.sciencedirect.com/science/article/pii/S0301008215301040

7. HIV-associated dementia. Neurodegener Dis [Internet]. Disponible en: https://www.karger.com/Article/Abstract/150539

8. HIV and the brain. Retrovirology [Internet]. Disponible en: https://retrovirology.biomedcentral.com/articles/10.1186/1742-4690-3-28

9. Neurocognitive impairment in HIV patients. IntechOpen [Internet]. Disponible en: https://www.intechopen.com/chapters/43845

10. HIV-associated neurocognitive disorders: clinical aspects. Curr HIV Res [Internet]. Disponible en: https://link.springer.com/article/10.1007/s13365-019-00735-0

11. Advances in HIV neurocognitive disorders. Curr Opin Neurol [Internet]. Disponible en: https://link.springer.com/article/10.1007/s11904-016-0324-x

12. Neuroinflammation and HIV. Neurosci Biobehav Rev [Internet]. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1388245717301323

13. Cognitive impairment and HIV infection. AIDS Care [Internet]. Disponible en: https://www.tandfonline.com/doi/abs/10.1080/09540121.2013.819401

14. HIV-associated neurocognitive disorder. StatPearls [Internet]. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK442425/

15. Neuropsychiatric aspects of HIV. J Neuropsychiatry Clin Neurosci [Internet]. Disponible en: https://neuro.psychiatryonline.org/doi/full/10.1176/jnp.10.2.125

16. Organización Mundial de la Salud. Sitio oficial [Internet]. Disponible en: https://www.who.int/es

17. Ministerio de Salud de la Nación Argentina. Sitio oficial [Internet]. Disponible en: https://www.argentina.gob.ar/salud

18. Legislación sanitaria argentina. Ministerio de Salud [Internet]. Disponible en: https://e-legis-ar.msal.gov.ar/htdocs/legisalud/migration/html/6159.html

19. HIV and cognitive decline. AIDS Care [Internet]. Disponible en: https://www.tandfonline.com/doi/10.1080/09540121.2020.1738008

20. Neurocognitive impairment in HIV populations. AIDS Behav [Internet]. Disponible en: https://link.springer.com/article/10.1007/s10461-018-2297-9

21. Screening for HIV-associated neurocognitive disorders. Cochrane Database Syst Rev [Internet]. Disponible en: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010775.pub3/full

22. Power C, Selnes OA, Grim JA, McArthur JC. HIV Dementia Scale: a rapid screening test. J Acquir Immune Defic Syndr. 1995;8(3):273-278.

23. Heaton RK, Clifford DB, Franklin DR, Woods SP, Ake C, Vaida F, et al. HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: the CHARTER Study. Neurology. 2010;75(23):2087-2096.

24. Vivithanaporn P, Nelles K, DeBlock L, Newman SC, Gill MJ, Power C. Hepatitis C virus co-infection increases neurocognitive impairment severity and risk of death in treated HIV/AIDS. J Neurol Sci. 2012;312(1):45-51.

25. Comparison of scales to evaluate the progression of HIV-associated neurocognitive disorder. HIV Ther. 2010;4(3):371-379.

26. Simioni S, Cavassini M, Annoni JM, Rimbault Abraham A, Bourquin I, Schiffer V, et al. Cognitive dysfunction in HIV patients despite long-standing suppression of viremia. AIDS. 2010;24(9):1243-1250.

27. Ellis RJ, Evans SR, Clifford DB, Moo LR, McArthur JC, Collier AC, et al. Clinical validation of the NeuroScreen. J Neurovirol. 2005;11(6):503-511.

28. von Giesen HJ, Haslinger BA, Rohe S, Köller H, Arendt G. HIV Dementia Scale and psychomotor slowing: the best methods in screening for Neuro-AIDS. J Neuropsychiatry Clin Neurosci. 2005;17(2):185-191.

29. Janssen MAM, Bosch M, Koopmans PP, Kessels RPC. Validity of the Montreal Cognitive Assessment and the HIV Dementia Scale in the assessment of cognitive impairment in HIV-1 infected patients. J Neurovirol. 2015;21(4):383-390.

30. Ganasen KA, Fincham D, Smit J, Seedat S, Stein DJ. Utility of the HIV Dementia Scale in identifying HIV dementia in a South African sample. J Neurol Sci. 2008;269(1-2):62-64.

31. Skinner S, Adewale A, DeBlock L, Gill MJ, Power C. Neurocognitive screening tools in HIV/AIDS: comparative performance among patients exposed to antiretroviral therapy. HIV Med. 2009;10(4):246-252.

32. Milanini B, Wendelken LA, Esmaeili-Firidouni P, Chartier M, Crouch PC, Valcour V. The Montreal Cognitive Assessment to screen for cognitive impairment in HIV patients older than 60 years. J Acquir Immune Defic Syndr. 2014;67(1):67-70.

33. Neurocognitive impairment in HIV infection. Lancet Infect Dis [Internet]. Disponible en: https://www.sciencedirect.com/science/article/pii/S1474442218304034

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Copyright (c) 2024 Samir Augusto Lage Costa, Karla Bendezu (Author)